Graphene Nanotechnology
The WykesNeuroLab utilises implanted graphene-based technologies (transistor arrays and stimulating electrodes) to gain a better understanding of neurological disease pathology and to offer novel therapeutic options.
We have considerable experience with imaging modalities and in viral vector-mediated manipulation of brain cells. We complement our graphene transistor recordings by genetically manipulating cells using a targeted viral approach and/or by simultaneous imaging techniques, such as widefield calcium or cerebral blood flow imaging. A major focus is investigating the spatiotemporal interactions and impact of seizures and spreading depolarisationsin preclinical models of epilepsy, stroke, migraine and glioblastoma.
We work closely with the device material scientists and electrical engineers; Dr Anton Guimerà-Brunet at the Institute of Microelectronics of Barcelona (https://www.imb-cnm.csic.es/en/about-center/imb-cnm) & Prof Jose Garrido at the Catalan Institute of Nanoscience & Nanotechnology (https://icn2.cat/en/), to develop and characterise graphene-based nanotechnology in vivo.
